| 摘要 |
FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing quinazoline compound of the formula (A) or its pharmaceutically acceptable salt or solvate wherein R1 represents (C1-C4)-alkoxy-group; R2 represents (C1-C6)-alkoxy-group; R3 represents 6-membered heterocyclic ring comprising at least one heteroatom taken among nitrogen atom (N); R4 represents 6-membered heterocyclic ring comprising at least one heteroatom taken among N and wherein this ring is optionally condensed with benzene ring. This ring system is optionally substituted with group NHSO2-(C1-C4-alkyl). Proposed method for preparing involves condensation of compound of the formula (B): wherein R1-R3 have above given values with compound of the formula (C): wherein R5 and R6 taken in common with nitrogen atom (N) to which they are bound represent 6-membered N-containing heterocyclic ring comprising at least one heteroatom taken among nitrogen atom (N). This ring is obligatory condensed with benzene ring and ring system if optionally substituted with group NHSO2-(C1-C4-alkyl). The condensation reaction is carried out in the presence of a base taken among tert.-butoxide sodium and tert.-pentoxide sodium and wherein conversion of prepared compound (A) to pharmaceutically acceptable salt or solvate is necessary or desirable, or conversion of prepared salt or solvate to compound of the formula (A). Except for, invention relates to methods for preparing compound of the formula (C) and compound of the formula (B) and compound of formulae (B) and (C). Invention provides minimal numbers of synthesis stages, elimination of carrying out competitive reactions and using danger materials. ^ EFFECT: improved preparing method. ^ 23 cl, 7 ex |
