| 摘要 |
Using biocompatible polymers (I), containing carboxy and O- or N-sulfonate substituents, in the production of pharmaceutical, dermatological or cosmetic compositions (A) or medical devices (B) for the prevention, alleviation and/or treatment of (or protection of tissue against) discomfort, distress, pruritis, irritation and/or pain, is new. The use of biocompatible polymers of formula (I) in the production of pharmaceutical, dermatological or cosmetic compositions (A) or medical devices (B) for the prevention, alleviation and/or treatment of (or protection of tissue against) discomfort, distress, pruritis, irritation and/or pain. AaXxYy (I) A : monomer; X : RCOOR'; Y : O- or N-sulfonate group attached to A, of formula -ROSO3R' or -NRSO3R'; R : linear or branched, saturated or unsaturated aliphatic hydrocarbon chain (optionally containing one or more aromatic rings); R' : H or a cation; a : number of monomer units; x : degree of substitution of the monomers A by X; and y : degree of substitution of the monomers A by Y. - ACTIVITY : Dermatological; Antipruritic; Analgesic; Vulnerary; Ophthalmological; Auditory; Antiinflammatory; Antiallergic; Antiulcer; Neuroprotective; Antipsoriatic; Antiasthmatic; Osteopathic; Antiarthritic; Gastrointestinal-Gen. Typically sunburn was treated using a polymer (Ia) consisting of dextran of molecular weight 2 kD which had been carboxymethylated (degree of substitution 0.4-0.5) and O-sulfated (degree of substitution 0.7-1). A solution of (Ia) (100 Microg/ml) in physiological saline containing methyl cellulose (in a amount sufficient to give a thin pasty consistency) was applied to the affected areas. Pain was alleviated within 10-30 minutes, and did not reappear the next day. - MECHANISM OF ACTION : None given.
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