发明名称 |
PREPARATION PROCESS OF OLIGOGLYCOSAMINOGLYCAN, AND REDUCING END GLUCURONIC ACID TYPE OLIGOCHONDROITIN SULFATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
<p>A sugar donor having a glucuronic acid or iduronic acid derivative at the reducing end and in which a leaving group is added to the reducing end hydroxyl group to be glycosylated and the other hydroxyl groups and the carboxyl groups are protected, is subjected to glycosylation reaction with a sugar acceptor having a N-acylgalactosamine derivative at the reducing end and in which the non-reducing end hydroxyl group to be glycosylated is free and the other hydroxyl groups are protected, in the presence of (A-3) a particular promoter. Provided is a process for preparing an oligoglycosaminoglycon of an intended chain length composed of four or more constituent sugars in highly stereoselectively, high yield and high purity.</p> |
申请公布号 |
WO2005092931(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
WO2005JP06439 |
申请日期 |
2005.03.25 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;TAMURA, JUN-ICHI;MATSUMOTO, TARO |
发明人 |
TAMURA, JUN-ICHI;MATSUMOTO, TARO |
分类号 |
C07H3/06;C07H5/06;C08B37/00;(IPC1-7):C08B37/00 |
主分类号 |
C07H3/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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