发明名称 |
CANCEROUS DISEASE MODIFYING ANTIBODIES |
摘要 |
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodie s can be conjugated to toxins, enzymes, radioactive compounds, and hematogenou s cells. The invention further relates to such diagnosis and treatment which revolves around the ability of the 5LAC~23 monoclonal antibody (or antigenic binding fragments derived therefrom) to bind with the Laminin Receptor 1 Precursor Protein 37LRP; and most particularly to diagnosis and treatment of Hepatocellular Carcinoma by various means which rely upon direct binding of 5LAC-23 with the particular antigenic moiety specifically recognized thereby and generally overexpressed in Hepatocellular carcinoma cells.
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申请公布号 |
CA2561192(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
CA20052561192 |
申请日期 |
2005.03.29 |
申请人 |
ARIUS RESEARCH, INC.;OXFORD BIOMEDICA UK LTD. |
发明人 |
KELLEHER, MICHELLE;WARNER, ANDREA;YOUNG, DAVID S. F.;HAHN, SUSAN E.;FINDLAY, HELEN P.;MCCONKEY, FORTUNATA |
分类号 |
C12N5/12;A61K39/395;A61K47/48;A61K51/10;A61P35/00;C07K16/30;G01N33/53;G01N33/566;G01N33/567;G01N33/574;G01N33/68 |
主分类号 |
C12N5/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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