发明名称 |
Compounds and methods for modulating VE-cadherin-mediated function |
摘要 |
Compositions and methods for modulating VE-cadherin-mediated functions are provided. The compositions and methods employ VE-cadherin modulating agents which generally comprise one or more of: (a) a peptide sequence that is at least 50% identical to a VE-cadherin cell adhesion recognition sequence; (b) a non-peptide mimetic of a VE-cadherin cell adhesion recognition sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a VE-cadherin cell adhesion recognition sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a VE-cadherin cell adhesion recognition sequence or analogue thereof.
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申请公布号 |
US2005222037(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
US20040004763 |
申请日期 |
2004.12.03 |
申请人 |
ADHEREX TECHNOLOGIES, INC. |
发明人 |
BLASCHUK OREST W.;GOUR BARBARA J.;SYMONDS JAMES M.;BYERS STEPHEN |
分类号 |
A61K38/00;C07K7/06;C07K14/705;(IPC1-7):A61K38/08;A61K38/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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