发明名称 |
METHOD OF DETECTING CONFORMATIONAL CHANGE OF AN AMYLOID PROTEIN, A METHOD OF SEARCHING A SUBSTANCE HAVING AN ACTIVITY THAT AFFECTS TO CONFORMATIONAL CHANGE OF AN AMYLOID PROTEIN, AND A METHOD OF SEARCHING A THERAPEUTIC OR DIAGNOSTIC AGENT FOR AMYLOID-RELATED DISEASES |
摘要 |
As the results of studies aiming at providing a means for real-time detectio n and assay of the amyloid protein aggregation process as a change in tension and/or elasticity with the use of a power sensor, a method of detecting an amyloid structural change in a protein with the use of a mechanochemical sensor is provided. Moreover, a method of searching for a substance having a n activity of affecting an amyloid structural change by using the above method , and a method of screening a remedy or a diagnostic for an amyloid-related disease are provided. These methods seemingly contribute to the acquisition of a novel remedy/diagnostic for an amyloid disease.
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申请公布号 |
CA2561246(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
CA20052561246 |
申请日期 |
2005.03.24 |
申请人 |
FUENCE CO., LTD. |
发明人 |
KASE, HIROSHI;TACHIBANA, MASAYOSHI;NONAKA, HIROMI |
分类号 |
G01N33/68;C12M1/40;C12Q1/26;G01N3/00;G01N3/02;G01N33/15;G01N33/50;G01N33/543 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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