发明名称 |
Chemokine mutants acting as chemokine antagonists |
摘要 |
Mutants of specific CC-chemokines containing a non-conservative substitution in a conserved consensus sequence act as CC-chemokine antagonists, and can be effectively used in the treatment of autoimmune and inflammatory diseases, cancers, and viral or bacterial infections. Particularly preferred are the RANTES/CCL5 mutants having the amino acid sequence of SEQ ID NO: 1, 2, 3, or 4.
|
申请公布号 |
US2005220757(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
US20050499100 |
申请日期 |
2005.02.18 |
申请人 |
PROUDFOOT AMANDA;KOSCO-VILBOIS MARIE;SHAW JEFFREY |
发明人 |
PROUDFOOT AMANDA;KOSCO-VILBOIS MARIE;SHAW JEFFREY |
分类号 |
C12N15/09;A61K38/00;A61K38/19;A61K45/00;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/06;C07K14/47;C07K14/52;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/19;C12P21/02;(IPC1-7):A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|