Method of treatment for stroke employing administration of defibrinogenating agents to achieve a specific defibrinogenation pattern

摘要

The present invention provides a method for the treatment of acute ischemic stroke based on a specific rate and pattern of defibrinogenation and subsequent refibrogenation associated with optimized efficacy and significantly improved safety. The administration of a single dose of defibrinogenating agent to achieve an optimal rate of defirinogenation avoids prolonged hypofibrinogenenemia and concomitant adverse side effects such as intracranial hemorrhage. The defibrinogenating agent is administered as a single dose and time-weighted end of treatment fibrinogen levels of >70 mg/dL are achieved by simply stopping administration of the defibrinogenating agent.