发明名称 |
Methods and composition of extended delivery of water insoluble drugs |
摘要 |
A pharmaceutical composition is provided that includes an active ingredient in the form of a powder or granule, a water soluble high molecular weight excipient and a water insoluble hydrophilic amphiphilic excipient. These ingredients are solution mixed and dried to form a modified pharmaceutical ingredient in simultaneous contact with both the water soluble high molecular weight excipient and the water insoluble hydrophilic amphiphilic excipient. Adjuvants are compacted about the modified pharmaceutical ingredient as well as a release control agent. The release control agent being present at levels from 1 to 40 total weight percent of the pharmaceutical composition.
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申请公布号 |
US2005220876(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
US20050097487 |
申请日期 |
2005.04.01 |
申请人 |
TSRL, INC. |
发明人 |
HILFINGER JOHN;KIM JAE S.;KIJEK PAUL |
分类号 |
A61K9/20;A61K9/28;A61K9/50;A61K31/225;A61K38/12;(IPC1-7):A61K38/12 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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