发明名称 1- or 3-Thia benzonaphthoazulenes as inhibitors oftumour necrosis factor production and intermediat es for the preparation thereof.
摘要 The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
申请公布号 ZA200408059(B) 申请公布日期 2005.10.06
申请号 ZA20040008059 申请日期 2004.10.06
申请人 PLIVA-ISTRAZIVACKI INSTITUT D.O.O. 发明人 MLADEN MERCEP;MILAN MESIC;DIJANA PESIC;IVANA OZIMEC;RUDOLF TROJKO
分类号 C07D495/04;A61K31/38;A61K31/381;A61K31/4025;A61K31/4535;A61K31/5377;A61P1/04;A61P9/00;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P19/06;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P37/02;A61P37/08;A61P43/00;C07D333/80;C07D337/16;C07D413/02 主分类号 C07D495/04
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