Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments

摘要

The invention relates to derivatives of 2-hydroxytetrahydrofuran corresponding to general formula (I) in which A represents the radical, in which R¹, R², R⁴, R⁵ and R⁶ represent (in particular), independently, H, a halogen atom, OH, alkyl or alkoxy, R³ represents H, alkyl or -COR¹⁰, R¹⁰ representing H, alkyl or alkoxy, and W represents a bond, -CH₂-CH₂-, -CH-CH-, -O-, -S- or -NR¹¹- in which R¹¹ represents H or alkyl; X represents -CO-, -Y-CO-, -O-Y-CO- or -NR¹²-Y-CO-, Y represents an alkylene or haloalkylene alkyl, R¹² represents H, alkyl or -COR¹³, R¹³ represents H, alkyl, haloalkyl or alkoxy, AA represents, each time that it occurs, a natural or non-natural amino acid; n represents 2 or 3; and finally R represents H, alkyl or -CO-R¹⁹, R¹⁹ representing alkyl. These compounds have a calpain inhibiting activity and/or an activity which traps the reactive oxygen species and can be used for preparing a medicament intended to treat the inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, cachexia, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.