| 摘要 |
PROBLEM TO BE SOLVED: To provide a permselective separation membrane which is good in the balance of separation characteristics, is high in safety and functional stability and is excellent in a module construction. SOLUTION: The permselective separation membrane of this invention mainly comprises a polysulfone polymer and polyvinyl pyrrolidone (PVP), wherein the existing proportion of PVP in a surface top layer of the membrane at the blood non-contacting side is 25-50 mass%, (the existing proportion of PVP in a surface top layer at the blood non-contacting side)/(the existing proportion of PVP in a surface top layer at the blood contacting side)≥1.1, and the insoluble matter content is 30 mass% or less to total PVP existing in the separation membrane. When the cow blood of 37°C having 30% of hematocrit and 6-7 g/dl of total protein concentration which is added by sodium citrate is flown into the module which is made by charging with the above permselective separation membrane at the rate of 200 ml/minute and with the filtering flow rate of 20 ml/minute, a sieving coefficient of albumin after 15 minutes is 0.01 or more and 0.1 or less, and the sieving coefficient of albumin after 2 hours is 0.005 or more and less than 0.04. COPYRIGHT: (C)2006,JPO&NCIPI
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