CYTOTOXICITY MEDIATION OF CELLS EVIDENCING SURFACE EXPRESSION OF MCSP

摘要

The use of a cancerous disease modifying antibody (CDMAB) 11 BD-2E11-2 for treating a tumor in humans and methods of isolating and identifying cancerou s cells which express a melanoma-associated chondroitin sulfate proteoglycan (MCSP) antigenic moiety. The monoclonal antibody 11 BD-2E11-2 (ATCC accessio n number PTA-5643), which binds a MCSP antigenic moiety, is cytotoxic to cance r cells which express the antigenic moiety. The monoclonal antibody 11 BD-2E11 -2 is useful for delaying the disease progression of a human tumor.