METHOD FOR MILLING FROZEN MICROPARTICLES

摘要

A method for forming microparticles include fragments solid particles that include a biologically active agent, a biocompatible polymer and a solvent, thereby producing fragments solid particles, and separating the solvent from the fragmented solid particles, thereby forming the micropraticles. The method can also include the steps of forming a mixture of the biologically active agent, the biocompatible polymer and the solvent, and freezing the mixture to form the solid particles. The present invention also relates to methods for producing injectable pharmaceutical compositions that include an injectable microparticle population.