发明名称 |
METHOD AND DEVICE FOR PROVIDING A DEFINED FLUID FLOW, ESPECIALLY FOR USE IN LIQUID CHROMATOGRAPHY |
摘要 |
The invention relates to a method for providing a defined fluid flow, especially for use in liquid chromatography. According to the method, a constant total flow (f0) is subdivided into an internal excess flow (fie) in an excess branch and into an internal working flow (fiw) in a working branch. The ratio of subdivision of the internal working flow (fiw) and the internal excess flow (fie) depends on the reverse ratio of a fluidic resistance provided in the working branch and a fluidic resistance in the excess branch. The excess branch and the working branch are interlinked at the respective outputs of the two fluidic outputs of the fluidic resistances by a cross-branch. The equalizing flow occurring between the outputs of the fluidic resistances is measured by means of a flow sensor. A desired, external working flow in the further course of the working branch can be fed to a working device, for example a chromatography column mounted downstream of the device. Further down the excess branch a variable fluidic resistance device is arranged. The resistance value of the variable fluidic resistance device is controlled, thereby controlling the equalizing flow in such a manner that the equalizing flow, preferably in the temporal mean, is substantially zero or equals a defined offset value whose amount is small compared to the internal working flow (fiw). The invention also relates to a device for carrying out the inventive method. |
申请公布号 |
WO2005062036(A3) |
申请公布日期 |
2005.10.06 |
申请号 |
WO2004DE02589 |
申请日期 |
2004.11.23 |
申请人 |
DIONEX SOFTRON GMBH;RUEGENBERG, GERVIN;HOCHGRAEBER, HERMANN |
发明人 |
RUEGENBERG, GERVIN;HOCHGRAEBER, HERMANN |
分类号 |
G01N30/32 |
主分类号 |
G01N30/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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