发明名称 |
GLYCOL LINKED FGF-21 COMPOUNDS |
摘要 |
The invention provides FGF-21 compounds covalently attached to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active polypeptide with an extended elimination half-life and a slower clearance when compared to that of non-PEGylated polypeptide. These PEGylated FGF-21 compounds and compositions are useful in treating diabetes, obesity, and metabolic syndrome.
|
申请公布号 |
CA2557782(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
CA20052557782 |
申请日期 |
2005.03.04 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
TSCHANG, SHENG-HUNG RAINBOW;MILLICAN, ROHN LEE JR.;RATHNACHALAM, RADHAKRISHNAN;GLAESNER, WOLFGANG |
分类号 |
A61K38/18;A61P3/00;C07K14/50 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|