| 摘要 |
The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R<SUP>1 </SUP>is C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, substituted C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl, substituted C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl, C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl-C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, substituted C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl-C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R<SUP>2 </SUP>is hydrogen, C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl-C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, or a group of formula II R<SUP>3 </SUP>is hydrogen or C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl; R<SUP>4 </SUP>is hydrogen, halo, or C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl; R<SUP>5 </SUP>is hydrogen or C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl; R<SUP>6 </SUP>is hydrogen or C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5 -HT<SUB>1F </SUB>receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
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