发明名称 |
Smac-peptides as therapeutics against cancer and autoimmune diseases |
摘要 |
The invention is directed to the use of Smac to sensitize different tumors and self-reactive immune cells to various pro-apoptosic stimuli, in that the cells subsequently undergo apoptosis. Therefore, Smac can be used as a compound for the manufacture of a medicament for the treatment of cancer and autoimmune diseases. Sensitization of the cells is achieved either by applying a cell-permeable form of Smac combined with known anticancer agents or by overexpression of the protein. It is an object of the invention to provide a new method in cancer and autoimmune disease therapy by using Smac agonists for apoptosis regulation. Thus, Smac agonists represent novel promising cancer and autoimmune disease therapeutics to potentiate the efficacy of cytotoxic therapies even in resistant tumors and immune cells.
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申请公布号 |
US2005222387(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
US20050511037 |
申请日期 |
2005.01.19 |
申请人 |
DEUTSCHES KREBSFORSCHUNGZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS |
发明人 |
DEBATIN KLAUS M.;FULDA SIMONE |
分类号 |
C12N15/09;A61K31/704;A61K31/7048;A61K33/24;A61K38/00;A61K38/17;A61K39/395;A61K45/00;A61K47/42;A61K47/48;A61P1/16;A61P3/10;A61P5/14;A61P5/40;A61P7/00;A61P7/06;A61P9/00;A61P9/14;A61P13/12;A61P15/00;A61P17/00;A61P19/02;A61P21/00;A61P21/04;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P31/00;A61P31/10;A61P31/18;A61P33/06;A61P35/00;A61P35/02;A61P37/06;C07K5/103;C07K14/11;C07K14/47;C07K14/50;C12N15/12;(IPC1-7):A61K38/17;C07K14/16;C07K14/475;C07K14/705 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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