USES OF ANTI-CTLA-4 ANTIBODIES

摘要

The invention relates to treatment of cancer in a mammal who has undergone stem cell transplantation by administering an effective amount of a human an ti- CTLA-4 antibody to the mammal. Stem cell transplantation may be allogeneic o r autologous stem cell transplantation and may be preceded by a preparatory treatment such as chemotherapy. The methods of the invention may be combined with additional cancer treatments. Further, the invention relates to treatme nt of cancer using at least 10 mg/kg of a human anti-CTLA-4 antibody, and, more preferably, about 15-20 mg/kg of antibody.