摘要 |
The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula -(CR<SUP>1</SUP>R<SUP>2</SUP>)<SUB>m</SUB>- (wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>are the same as or different from each other and each represents a C<SUB>1-6 </SUB>alkyl group etc.), -NR<SUP>3</SUP>- (wherein R<SUP>3 </SUP>represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula -(CR<SUP>6</SUP>R<SUP>7</SUP>)<SUB>p</SUB>- (wherein R<SUP>6</SUP>and R<SUP>7 </SUP>are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C<SUB>1-6 </SUB>alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C<SUB>1-6 </SUB>alkyl group etc.; and the partial structure <img id="CUSTOM-CHARACTER-00001" he="2.12mm" wi="5.67mm" file="US06951865-20051004-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/> means a single or double bond.
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