| 摘要 |
Benzothiazine and benzothiadiazine compounds of formula (I), their isomers and addition salts pharmaceutical compositions, and preparation process thereof are disclosed, wherein: R1 represents hydrogen, halogen or a linear or branched (C1-C6)alkyl group; R1a represents hydrogen or a linear or branched (C1-C6)alkyl group; R2 represents hydrogen, halogen or a hydroxy; A represents CR4R5 or NR4; R3 represents hydrogen, a linear or branched (C1-C6)alkyl or a (C3-C7)cycloalkyl group; R4 represents hydrogen or a linear or branched (C1-C6)alkyl group; or A represents a nitrogen and together with the adjacent -CHR3- group, forms the ring as defined in the specification; R5 represents hydrogen or halogen; and X represents an NR6R7, S(O)nR8 or OR'8, wherein R6, R7 R8 and R'8 are as defined in the specification. These benzothiazine and benzothiadiazine compounds of formula (I) are useful as AMPA modulators.
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