Phosphoprotein target for insulin and its antagonists

摘要

A method for screening for an agent useful for treatment of insulin resistance comprising contacting a mammalian cell expressing P20 and the agent and determining if the agent suppresses the level of at least one of P20 isoforms S2 and S3, wherein the suppression of S2 and S3 levels is indicative of an agent useful for treatment of insulin resistance. Also disclosed is a method for diagnosing insulin resistance in an individual comprising obtaining a biological sample from the individual and determining a level of at least one of P20 isoforms S2 and S3, wherein the individual is diagnosed as being insulin resistant when the level of expression of at least one of S2 and S3 is higher than a reference level characteristic of an individual not suffering from insulin resistance.