摘要 |
A compound of the general formulae (I) or (II) is described wherein R1, R2, R3, R4, R5, R6, R7, and R8 are independently hydrogen, hydroxy, OR9, OC(O)H, OC(O)R9, OS(O)R9, OSi(R10)3, C(O)R11, CO2R12, alkyl, haloalkyl, aryl, arylalkyl, thio, alkylthio, amino, alkylamino, dialkylamino, nitro or halo; R9 is alkyl, haloalkyl, aryl, arylalkyl or alkylaryl; R10 is indepen-dently hydrogen, alkyl or aryl; R11 is hydrogen, alkyl, aryl, arylalkyl or an amino acid; and R12 is hydrogen, alkyl, haloalkyl, aryl or arylalkyl; X is O, NR4 or S, and the drawing "---" represents either a single bond or a double bond. A proviso explains that in formula (I) at least one of R5, R6, R7, and R8 is hydrogen; and certain compounds are disclosed to be explicitly excluded. The compounds are described to be used in the manufacture of a medicament for the treatment of a disease selected from those including cancer, inflammatory reactions, papulonodular skin lesions, and autoimmune diseases.
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