NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS.

摘要

where; R1 is O, S; R2 is a nitrogen-containing heterocycle; R3 is H, Cl-C3 alkyl; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -O-, -S-, -S(=O)- or -S(=O)2-; n and m are independently 0, 1 or 2, R8 and R8' are independently H, C1-C3 alkyl, haloC1-C3alkyl, hydroxy, or R8 and R8' together with their adjacent C atom is -C(=O)-; R9 is independently H, C1-C3 alkyl; E is CH2-, -CHOH-, -C(=O)-, -NR9-, -O-, -S-, -S(=O)2-; n and m are independently 0, 1 or 2; p and q are independently 0, 1 or 2, where p+q <= 2; R10 is an optionally substituted carbocycle or heterocycle; R11 is independently H, C1-C3 alkyl, halo substituted Cl-C3alkyl, hydroxy; have utility as HIV antivirals.