Compositions comprising microaggregates of photosensitizers and phospholipids

摘要

Compositions comprising microaggregates smaller than 100 nm containing hydrophobic drugs, particularly photosensitizers, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds, namely saturated and unsaturated phospholipids, and processing conditions favoring the production of small aggregates for improved filter sterilization.