| 摘要 |
THE PRESENT INVENTION CONCERNS NOVEL COMPOUNDS OF FORMULA FORMULA THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN L REPRESENT A RADICAL OF FORMULA FORMULA WHEREIN EACH ALK INDEPENDENTLY REPRESENTS AN OPTIONALLY SUBSTITUTED C1-6ALKANEDIYL; N IS 1, 2 OR 3; Y IS O, S OR NR2; R1 REPRESENTS ARYL, HET1, OR AN OPTIONALLY SUBSTITUTED C1-6ALKYL; R2 REPRESENTS HYDROGEN; OR IN CASE R1 AND R2 ARE ATTACHED TO THE SAME NITROGEN ATOM, THEY MAY BE TAKEN TOGETHER TO FORM A HETEROCYCLIC RADICAL; OR THEY MAY BE TAKEN TOGETHER TO FORM AN AZIDO RADICAL; EACH R3 INDEPENDENTLY REPRESENTS HYDROGEN, HYDROXY OR C1-4ALKYLOXY; ARYL REPRESENTS PHENYL, NAPHTHALENYL, 1,2,3,4-TETRAHYDRO-NAPHTHALENYL, INDENYL OR INDANYL; EACH OF SAID ARYL GROUPS MAY OPTIONALLY BE SUBSTITUTED; HET1 REPRESENTS AN OPTIONALLY SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC RADICAL; HET2 IS THE SAME AS HET1 AND MAY ALSO BE PIPERAZINYL, HOMOPIPERAZINYL, 1,4-DIOXANYL, MORPHOLINYL, THIOMORPHOLINYL; R6 REPRESENTS HYDROGEN OR C1-4ALKYL; R7 REPRESENTS HYDROGEN OR C1-4ALKYL; OR R6 AND R7 TAKEN TOGETHER FORM A BIVALENT RADICAL OF FORMULA -N=CH- (I), -CH=N- (II), -CH=CH- (III), - CH2-CH2 (IV), WHEREIN ONE HYDROGEN ATOM IN THE RADICALS (I) AND (II) MAY BE REPLACED WITH A C1-4ALKYL RADICAL AND ONE OR MORE HYDROGEN ATOMS IN RADICALS (III) AND (IV) MAY BE REPLACED BY A C1-4ALKYL RADICAL; D REPRESENTS A TRISUBSTITUTED TETRAHYDROFURAN DERIVATIVE; AS ANTIFUNGALS; THEIR PROCESSES FOR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS A MEDICINE.
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