Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
申请公布号
WO2005073195(A3)
申请公布日期
2005.09.29
申请号
WO2005SE00097
申请日期
2005.01.28
申请人
MEDIVIR AB;ROSENQUIST, AASA;THORSTENSSON, FREDRIK;JOHANSSON, PER-OLA;KVARNSTROEM, INGEMAR;SAMUELSSON, BERTIL;WALLBERG, HANS
发明人
ROSENQUIST, AASA;THORSTENSSON, FREDRIK;JOHANSSON, PER-OLA;KVARNSTROEM, INGEMAR;SAMUELSSON, BERTIL;WALLBERG, HANS