摘要 |
The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations |
申请人 |
BECTON DICKINSON AND COMPANY;CAMPBELL, ROBERT;DOLAN, KEVIN, G.;ALARCON, JASON;WOODLEY, WENDY, D.;MIKSZTA, JOHN |
发明人 |
CAMPBELL, ROBERT;DOLAN, KEVIN, G.;ALARCON, JASON;WOODLEY, WENDY, D.;MIKSZTA, JOHN |