摘要 |
Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent. |
申请人 |
CUMBRE INC.;MA, ZHENKUN;JIN, YAFEI;LI, JING;DING, CHARLES, Z.;MINOR, KEITH, P.;LONGGOOD, JAMIE, C.;KIM, IN HO;HARRAN, SUSAN;COMBRINK, KEITH;MORRIS, TIMOTHY, W. |
发明人 |
MA, ZHENKUN;JIN, YAFEI;LI, JING;DING, CHARLES, Z.;MINOR, KEITH, P.;LONGGOOD, JAMIE, C.;KIM, IN HO;HARRAN, SUSAN;COMBRINK, KEITH;MORRIS, TIMOTHY, W. |