发明名称 |
METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION |
摘要 |
<p>The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.</p> |
申请公布号 |
CA2558371(A1) |
申请公布日期 |
2005.09.29 |
申请号 |
CA20052558371 |
申请日期 |
2005.03.14 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
KUCHROO, VIJAY K.;MEYERS, JENNIFER;STROM, TERRY;ZHENG, XIN XIAO;CHAKRAVARTI, SUMONE |
分类号 |
C12N15/11;A61K38/17;A61K39/395;A61K48/00;C07K14/705;C07K16/28;G01N33/576;G01N33/68 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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