| 发明名称 |
METHODS AND COMPOSITIONS FOR THE INHIBITION OF HIV-1 REPLICATION |
| 摘要 |
This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKNIA) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication. |
| 申请公布号 |
WO2005046732(A3) |
申请公布日期 |
2005.09.29 |
| 申请号 |
WO2004US36492 |
申请日期 |
2004.11.03 |
| 申请人 |
THE UNITED SATES OF AMERICA AS REPRESENTED BY THE;WAHL, SHARON, M.;VAZQUEZ-MALDONADO, NANCY;GREENWELL-WILD, TERESA |
发明人 |
WAHL, SHARON, M.;VAZQUEZ-MALDONADO, NANCY;GREENWELL-WILD, TERESA |
| 分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/113 |
主分类号 |
A61K38/00 |
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