METHOD AND KIT FOR SCREENING, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATMENT OF AUTOIMMUNE DISORDERS

摘要

The present invention relates to a method for screening and/or diagnosis of autoimmune disorders comprising the step of : a) obtaining biological sample from a test subject b) contacting the biological sample with at least one agent capable of detecting at least one of PDCD1, RUNX1, RUNX2 and/or RUNX3 nucleic acid or the corresponding expression product coded for by one or more of these genes or a subfragment thereof. d) comparing the expression rate of at least one expression product from PDCD1, RUNX1, RUNX2 and/or RUNX3 nucleic acid or a subfragment thereof from a healthy test subject with the expression rate thereof from another test subject. The invention also relates to a kit, a method for identifying compounds, that modulate PDCD1, RUNX1, RUNX2 or RUNX3 expression, a pharmaceutical composition comprising such a compound, the use of such a composition for the preparation of a pharmaceutical composition for the treatment of autoimmune diseases and a method for the treatment of a patient suffering from an autoimmune disease. The invention especially relates to systemic lupus erythematosus (SLE) and rheumatoid arthritis.