| 摘要 |
A compound (preferably bufeniode, denopamine, fenoterol, ifenprodil, isoxsuprine, labetol, medroxalol, mesuprine, nylidrin, protokylol, ractopamine, ritodrine, salmefamol or sulfinalol) that has utility in the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, and in particul ar a disease selected from the group consisting of rheumatoid arthritis, osteoarthritis, or osteoporosis, chronic demyelinating disease such as multiple sclerosis, respiratory diseases such as asthma or chronic obstructi ve pulmonary disease, inflammatory bowel disease (IBD) such as ulcerative colit is or Crohn~s disease, dermatological conditions such as psoriasis, scleroderma or atopic dermatitis, dental diseases such as periodontal disease or gingivitis, diabetic nephropathy, lupus nephritis, IgA nephropathy or glomerulonephritis, systemic iupus erythomatosus (SLE), graft vs host diseas e, a pain condition, is of formula (I), wherein R1 is H or Me; R2 is H or alkyl and R3 is H or Me, or R2 and R3 are -CH2- thereby forming a ring; n is 0 to 2; X is CH2 or O; and the two benzene rings are each optionally substituted wit h OH, OMe, halogen, NHCHO, NHSO2Me, CONH2, SOMe, OCH2O, or CH2OH.
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