| 摘要 |
<p>The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fab s and single chain antibodies, multivalent single chains antibodies, diabodies , triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non- cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.</p> |
