发明名称 |
NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES |
摘要 |
<p>The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula (I) wherein R1 is a group of the formula G1 or G2 depicted below, wherein R1, R3, R6, R13, X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.</p> |
申请公布号 |
WO2005090300(A1) |
申请公布日期 |
2005.09.29 |
申请号 |
WO2005IB00583 |
申请日期 |
2005.03.07 |
申请人 |
PFIZER PRODUCTS INC.;BRODNEY, MICHAEL, AARON;CARON, STEPHANE;HELAL, CHRISTOPHER, J.;RAGGON, JEFFREY, W.;TAO, YONG;DO, NGA, M. |
发明人 |
BRODNEY, MICHAEL, AARON;CARON, STEPHANE;HELAL, CHRISTOPHER, J.;RAGGON, JEFFREY, W.;TAO, YONG;DO, NGA, M. |
分类号 |
A61K31/496;A61K31/5377;C07D207/26;C07D211/76;C07D401/04;C07D401/10;C07D403/10;C07D405/04;C07D405/10;C07D405/14;C07D413/10;C07D413/14;(IPC1-7):C07D207/26;A61K31/401;A61K31/402;A61K31/45;A61K31/452;A61P25/00 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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