发明名称 |
PROSTAGLANDIN ENDOPEROXYDE H SYNTHASE BIOSYNTHESE INHIBITOREN |
摘要 |
The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs). |
申请公布号 |
DE69926903(D1) |
申请公布日期 |
2005.09.29 |
申请号 |
DE1999626903 |
申请日期 |
1999.10.27 |
申请人 |
ABBOTT LABORATORIES, ABBOTT PARK |
发明人 |
BLACK, A.;BASHA, ANWER;KOLASA, TEODOZYJ;KORT, E.;LIU, HUAQING;MCCARTY, M.;PATEL, V.;ROHDE, J.;COGHLAN, J.;STEWART, O. |
分类号 |
A61K31/50;A61K31/501;A61P19/02;A61P25/04;A61P29/00;A61P35/00;C07D237/14;C07D237/16;C07D237/18;C07D237/22;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/10;C07D403/12;C07D405/04;C07D405/12;C07D409/04;C07D409/06;C07D409/12;C07D413/04;C07D413/12;C07D417/06;(IPC1-7):C07D237/14 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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