发明名称 |
DNA coding for human cell surface antigen |
摘要 |
DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are proveded. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas cDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.
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申请公布号 |
US6949360(B2) |
申请公布日期 |
2005.09.27 |
申请号 |
US20010884987 |
申请日期 |
2001.06.21 |
申请人 |
OSAKA BIOSCIENCE INSTITUTE |
发明人 |
NAGATA SHIGEKAZU;ITOH NAOTO;YONEHARA SHIN |
分类号 |
A61K38/00;C07K14/715;C07K16/28;C12N1/21;C12N15/12;C12P21/08;(IPC1-7):C12N15/12;C12N15/63;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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