Thiazole and oxazole derivatives

摘要

A compound of the formula (I): wherein R¹ is hydroxy and the like; R² is optionally substituted lower alkyl and the like; R³ is hydrogen atom and the like; R⁴ is optionally substituted arylene and the like; R⁵ is a group represented by the formula: and the like; R⁶ is optionally substituted aryl and the like, its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof and metalloproteinase inhibitors containing them.