| 发明名称 |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives |
| 摘要 |
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R<SUP>1 </SUP>and R<SUP>2 </SUP>include alkyl and phenylalkyl; R<SUP>3 </SUP>is hydrogen or alkyl; and R<SUB>4 </SUB>and R<SUB>5 </SUB>include alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).
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| 申请公布号 |
US6949575(B2) |
申请公布日期 |
2005.09.27 |
| 申请号 |
US20020275351 |
申请日期 |
2002.11.04 |
| 申请人 |
PFIZER INC. |
发明人 |
BARTA NANCY SUE;BIGGE CHRISTOPHER FRANKLIN |
| 分类号 |
A61K9/08;A61K9/20;A61K9/70;A61K31/196;A61K31/245;A61K49/00;A61K51/00;A61P3/10;A61P5/14;A61P7/06;A61P9/00;A61P19/08;A61P21/00;A61P25/00;A61P25/16;A61P25/28;A61P31/04;A61P35/00;A61P43/00;C07C229/56;C07C229/58;C07C229/60;C07C229/64;(IPC1-7):A01N43/64;A01N37/12;A01N37/44;A61K31/24;A61K31/41 |
主分类号 |
A61K9/08 |
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