DNA CHIP AND METHOD OF EXTRACTING DISEASE-ASSOCIATED GENES

摘要

[PROBLEMS] To provide a method of extracting genes associated with a subject disease by using a DNA chip and to provide a DNA chip having the genes extracted by this method. [MEANS FOR SOLVING PROBLEMS] Genes associated with a subject disease can be extracted by: (A) extracting a first group of genes showing a difference in expression amount by using a DNA chip based on a control mRNA prepared from a nonhuman control animal and a disease mRNA prepared from a diseased animal which belongs to the same species as the control animal and suffers from the subject disease; (B) extracting a second group of genes showing a difference in expression amount by using a DNA chip based on a regulatory mRNA prepared from a regulated animal having been subjected to a preventive or therapeutic treatment for the disease and the control mRNA; and (C) further extracting a group of genes showing tendencies opposite to each other in the first and second gene groups.