发明名称 |
Rifamycin imino derivatives effective against drug-resistant microbes |
摘要 |
The present invention relates to rifamycin 3-iminomethylenyl (-CH-N-) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (-CH-N-) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.
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申请公布号 |
US2005209210(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20050034279 |
申请日期 |
2005.01.12 |
申请人 |
CUMBRE INC. |
发明人 |
DING CHARLES Z.;JIN YAFEI;LONGGOOD JAMIE C.;MA ZHENKUN;LI JING;KIM IN H.;MINOR KEITH P.;HARRAN SUSAN |
分类号 |
A61K31/4709;C07D491/14;C07D498/08;C07D519/00;(IPC1-7):A61K31/470 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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