Enhancement of hematopoietic stem cell survival

摘要

A composition is disclosed that includes lin^- cells that are characterized as expressing CD31, CD34 and CD105, and not expressing c-kit, wherein the composition comprises fewer than 20% of lineage committed cells. Methods are disclosed for isolating CD31⁺CD34⁺CD45^-CD105⁺c-kit^- cells. Methods for reconstituting hematopoiesis using compositions including CD31⁺CD34⁺CD105⁺CD45^-kit^- cells are also disclosed.