| 发明名称 |
Tec kinase inhibitors |
| 摘要 |
Disclosed are compounds of formula(I): wherein Ar<SUB>1</SUB>, Ar<SUB>2</SUB>, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4 </SUB>and X<SUB>a </SUB>are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
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| 申请公布号 |
US2005209284(A1) |
申请公布日期 |
2005.09.22 |
| 申请号 |
US20050055798 |
申请日期 |
2005.02.09 |
| 申请人 |
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. |
发明人 |
BENTZIEN JOERG M.;COOK BRIAN N.;LI XIANG;LO HO Y.;MAN CHUK C.;MUGGE INGO A.;NEMOTO PETER A.;PULLEN STEVEN S.;RIETHER DORIS E.;ROTH GREGORY P.;SOLEYMANZADEH FARIBA;TAKAHASHI HIDENORI;WANG JI;WHITE ANDRE;ZINDELL RENEE |
| 分类号 |
A61K31/4184;A61K31/422;A61K31/427;A61K31/4439;C07D235/30;C07D401/14;C07D409/12;C07D409/14;C07D413/02;C07D413/12;C07D413/14;C07D417/02;C07D417/14;C07D491/10;(IPC1-7):A61K31/443;C07D43/02;A61K31/418 |
主分类号 |
A61K31/4184 |
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