发明名称 |
Process for the preparation of 1 - (3-dimethylaminopropyl) -1 - (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-carbonitrile |
摘要 |
The present invention is directed to novel processes for the preparation of citalopram comprising halogenation of a phthalide compound of formula II, wherein R is a suitable group to be changed to CN, to afford an acid halogenide compound of formula III wherein R is as defined as above and X is halogen, and thereafter obtaining citalopram through two successive reactions with suitable organometallic halides or organoboranes or by a reaction with organometallic 4-fluorophenylhalide or 4-fluorophenylborane followed by reduction and alkylation, and an exchange of R to cyano to afford citalopram. The order of the reactions can be varied depending for example on the starting compound used.
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申请公布号 |
US2005209467(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20050045087 |
申请日期 |
2005.01.31 |
申请人 |
FERMION OY |
发明人 |
HILDEN LEIF;RUMMAKKO PETTERI;GRUMANN ARNE;PIETIKAEINEN PEKKA |
分类号 |
C07C51/60;C07C63/70;C07D307/87;(IPC1-7):C07D307/87 |
主分类号 |
C07C51/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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