SOLID PHARMACEUTICAL PREPARATION COMPOSITION COMPRISING FINE PARTICULATE ACTIVE INGREDIENT AND POROUS CELLULOSE AGGREGATE

摘要

PROBLEM TO BE SOLVED: To obtain a solid pharmaceutical preparation composition having a high mixing speed of active ingredients and small dispersion of concentration in a solid pharmaceutical preparation comprising various kinds of active ingredients, especially finely pulverized active ingredients by using a porous cellulose aggregate having a large intraparticle pore volume.

SOLUTION: This solid pharmaceutical preparation composition comprises the one or more kinds of active ingredients finely pulverized to ≤40 μm and the porous cellulose aggregate. Furthermore, the porous cellulose aggregate has a secondary aggregate structure in which cellulose primary particles are aggregated and has ≥0.265 cm3/g intraparticle pore volume, contains I type crystals and has >30 μm average particle diameter, 1.3-20 m2/g specific surface area and <44° angle of repose and disintegrates in water.

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