发明名称 |
Immunogenic compositions for induction of anti-tumor immunity |
摘要 |
The invention relates to methods of inducing an anti-tumor immunity and/or inducing an immune responses to p53 in mammals. The methods comprise administering to a mammal an effective amount of at least one immunogen selected from the group consisting of: (i) a peptide based on a CDR of the heavy or light chain of an anti-p53 mAb, which peptide is capable of eliciting antibodies to p53; and (ii) a DNA molecule coding for the variable (V) region of an anti-p53 mAb in a suitable gene delivery vehicle. Preferably the immunogen is administered in the form of a pharmaceutical composition. Preferably the peptide is 7 to 30 amino acid residues in length and contains a sequence of the CDR2 or CDR3 of the heavy chain, or of the CDR3 of the light chain of an anti-p53 mAb.
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申请公布号 |
US2005208065(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20050129359 |
申请日期 |
2005.05.16 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
COHEN IRUN R.;ROTTER VARDA;WOLKOWICZ ROLAND;RUIZ PEDRO;EREZ-ALON NETA;HERKEL JOHANNES |
分类号 |
A61K39/00;A61K48/00;A61P35/00;A61P37/04;C07K16/18;C07K16/30;(IPC1-7):A61K48/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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