| 摘要 |
Methods of identifying insulin response modulators are provided. In particular, methods that feature identifying modulators of Akt and its associated substrates (including R-type calcium channel alpha-1E subunit (R-CaC1E), WNK1, FMS interacting protein (FMIP), nGAP-like protein, nuclear matrix protein p84, HIRA interacting protein 3 (HIRIP3), HSP71, ribosomal protein L6, guanine nucleotide exchange factor Lbc (GEF Lbc), ATP citrate lyase, Mi-2b, peripheral benzodiazepine receptor-associated protein 1, heterogeneous nuclear ribonucleoprotein U (hnRNP U protein), pyruvate carboxylase precursor, Eps domain containing protein (RalBP1), nonmuscle myosin IIA (NMMIIA), and stress 70 protein (p66 mot1/GRP75), or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided.
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