A HUMANIZED ANTI-CEA T84.66 ANTIBODY AND USES THEREOF
摘要
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.
申请公布号
WO2005086875(A2)
申请公布日期
2005.09.22
申请号
WO2005US07831
申请日期
2005.03.11
申请人
CITY OF HOPE;YAZAKI, PAUL, J.;SHERMAN, MARK, A.;SHIVELY, JOHN, E..;RAUBITSCHEK, ANDREW, A.;WU, ANNA, M.