发明名称 |
Substantially pure solid form of the enol tautomer of 3-indolypyruvic acid for use in the treatmetn of central nervous system disturbances |
摘要 |
The enol tautomer of 3-indolylpyruvic acid in stable and pure form, as well as alkali and alkali-earth salts thereof are produced by synthesis process. The enol tautomer comprises only the geometric isomer (Z) and it is the only one tautomeric form having relevant pharmacological effects. The compounds obtained exhibited relevant biochemical and pharmacological properties in pathological situations like anxiety, depression, behaviour disturbances, neuronal degenerations, etc.
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申请公布号 |
US2005208125(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20050513859 |
申请日期 |
2005.05.31 |
申请人 |
POLITI VINCENZO;SELLA ANTONIO;BARTOLINI BARBARA;MARGONELLI ANDREA;SOMMA FRANCESCA;CORNIELLO CRISTINA |
发明人 |
POLITI VINCENZO;SELLA ANTONIO;BARTOLINI BARBARA;MARGONELLI ANDREA;SOMMA FRANCESCA;CORNIELLO CRISTINA |
分类号 |
A61K31/405;A61P9/10;A61P25/00;A61P25/08;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P35/00;C07D209/18;(IPC1-7):C07D209/18;A61K9/48;A61K9/20 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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