PTPN22 POLYMORPHISMS IN DIAGNOSIS AND THERAPY

摘要

The invention provides 1) methods and compositions for detecting polymorphisms of the PTPN22 genomic DNA; 2) methods for associating polymorphisms of the PTPN22 gene with the occurrence of an immune disorder, inflammatory disorder or cell proliferation disorder; 3) methods for identifying subjects at risk of an immune disorder, inflammatory disorder or cell proliferation disorder by determining if they have a polymorphism of the PTPN22 gene and treating such subjects with a tyrosine kinase inhibitor to prevent or delay the progression of such diseases; 4) methods for identifying subjects having an immune disorder, inflammatory disorder or cell proliferation disorder who are promising candidates for therapy with a tyrosine kinase inhibitor by determining if such subjects have a polymorphism of the PTPN22 gene; and 5) methods of treating subjects having an immune disorder, inflammatory disorder or cell proliferation disorder mediated by a polymorphism of the PTPN22 gene by administering to such subjects a tyrosine kinase inhibitor.